QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP STUDIES ON SOME ACYCLOURIDINE DERIVATIVES ACTING AS ANTI-HIV-1 DRUGS

Authors
GARG R KURUP A GUPTA SP
Citation
R. Garg et al., QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP STUDIES ON SOME ACYCLOURIDINE DERIVATIVES ACTING AS ANTI-HIV-1 DRUGS, Quantitative structure-activity relationships, 16(1), 1997, pp. 20-24
Citations number
13
Categorie Soggetti
Pharmacology & Pharmacy","Chemistry Medicinal
Journal title
Quantitative structure-activity relationships → ACNP
ISSN journal
09318771
Volume
16
Issue
1
Year of publication
1997
Pages
20 - 24
Database
ISI
SICI code
0931-8771(1997)16:1<20:QSRSOS>2.0.ZU;2-9
Abstract
The anti-HIV-1 activity of some derivatives of 1-[2-hydroxyethoxy]-6-( phenylthio)thymine(HEPT) is analyzed in relation to their physicochemi cal and molecular properties. The activities of the compounds are foun d to be significantly correlated with hydrophobic constant 71 and the van der Waals volume V-w. The results are found to be useful in discus sing the mechanism of drug-receptor interaction.