R. Garg et al., QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP STUDIES ON SOME ACYCLOURIDINE DERIVATIVES ACTING AS ANTI-HIV-1 DRUGS, Quantitative structure-activity relationships, 16(1), 1997, pp. 20-24
The anti-HIV-1 activity of some derivatives of 1-[2-hydroxyethoxy]-6-(
phenylthio)thymine(HEPT) is analyzed in relation to their physicochemi
cal and molecular properties. The activities of the compounds are foun
d to be significantly correlated with hydrophobic constant 71 and the
van der Waals volume V-w. The results are found to be useful in discus
sing the mechanism of drug-receptor interaction.