Objectives-Sewer workers are used to unpleasant smells, but may be req
uired to investigate unusual ones. Twenty six men were involved in inv
estigation of episodes of such a smell after neighbourhood complaints
over several weeks. Methods-Workers exposed to the smell were investig
ated by clinical follow up, lung function tests, and measurement of pi
tuitary function. Results-14 of the 26 developed subacute symptoms inc
luding sore throat, cough, chest tightness, breathlessness, thirst, sw
eating, irritability, and loss of libido. Severity of symptoms seemed
to be dose related. Minor symptoms resolved over several weeks but tho
se more seriously affected have shown deteriorating respiratory sympto
ms and lung function and remain unable to work a year after the incide
nt. In one, evidence of mild cranial diabetes insipidus was found. Ana
lysis of gas from the sewer showed the presence of a mixture of thiols
and sulphides, known to be highly odorous and not normally found in s
ewers. The source remains unknown. Conclusions-Several of these men se
em to have developed delayed airways disease and disturbances of hypot
halamic function. Such an outcome has not to our knowledge been descri
bed before. Despite the presence of the smell, standard safety gas det
ection equipment used to ensure the sewer was safe to enter failed to
indicate the presence of a hazard. Protection against such incidents c
an only be provided by the use of positive pressure breathing apparatu
s.