SIMPLE SPECTROPHOTOMETRIC DETERMINATION OF TINIDAZOLE IN FORMULATION AND SERUM

A simple and rapid spectrophotometric method for the determination of tinidazole is presented. This method is based on the measurement of th e absorbance of the signal at 368 nm yielded by bathochromic shift dur ing alkaline hydrolysis of tinidazole in 0.1N NaOH. The method is line ar within the range of 1-30 mu g ml(-1), and the detection and quantif ication limits are 0.07 and 0.25 mu g ml(-1), respectively. The precis ion of the method, expressed as the relative standard deviation, is 0. 19% for a tinidazole concentration of 15 mu g ml(-1). The method was a pplied to the analysis of tinidazole in pharmaceutical formulations an d serum.