LATE RENAL-ALLOGRAFT FAILURE SECONDARY TO THROMBOTIC MICROANGIOPATHY ASSOCIATED WITH DISSEMINATED MALIGNANCY

A renal transplant recipient with a remote history of end-stage renal disease due to postpartum hemolytic-uremic syndrome (HUS) presented wi th acute renal failure after having stable renal allograft function fo r 9 years. A diagnosis of thrombotic microangiopathy was made based on clinical and histologic findings at renal biopsy. She was treated con servatively, never regaining graft function and ultimately succumbing from her overwhelming tumor load approximately 6 months following diag nosis of her malignancy. To our knowledge, this is the first report of thrombotic microangiopathy associated with disseminated malignancy re sulting in renal allograft failure.