DOUBLE-BLIND, RANDOMIZED CLINICAL-TRIAL FOR SAFETY AND EFFICACY OF NORFLOXACIN FOR SHIGELLOSIS IN CHILDREN

Authors
BHATTACHARYA SK BHATTACHARYA MK DUTTA D DUTTA S DEB M DEB A DAS KP KOLEY H NAIR GB
Citation
Sk. Bhattacharya et al., DOUBLE-BLIND, RANDOMIZED CLINICAL-TRIAL FOR SAFETY AND EFFICACY OF NORFLOXACIN FOR SHIGELLOSIS IN CHILDREN, Acta paediatrica, 86(3), 1997, pp. 319-320
Citations number
9
Categorie Soggetti
Pediatrics
Journal title
Acta paediatrica → ACNP
ISSN journal
08035253
Volume
86
Issue
3
Year of publication
1997
Pages
319 - 320
Database
ISI
SICI code
0803-5253(1997)86:3<319:DRCFSA>2.0.ZU;2-F
Abstract
In a randomized, double-blind clinical trial, the efficacy and safety of norfloxacin were compared with nalidixic acid in the treatment of s higellosis in children. Out of 59 cases, Shigella spp. were isolated f rom 8 cases in the nalidixic acid group and 14 cases in the norfloxaci n group. The norfloxacin group had significantly less duration of diar rhoea and presence of blood in stool as compared to the nalidixic acid group. No joint problem was encountered in this study at up to 4 mont hs follow-up. Norfloxacin is safe and effective and showed no cartilag e toxicity on short-term follow-up.