G. Karthikeyan et al., PHOTOOXIDANT INJURY TO GLUCOSE-6-PHOSPHATE DEHYDROGENASE-DEFICIENT ERYTHROCYTES WITH BILIRUBIN AS THE SENSITIZER - AN IN-VITRO STUDY, Acta paediatrica, 86(3), 1997, pp. 321-322
To evaluate the hypothesis that glucose-6-phosphate dehydrogenase (G6P
D)-deficient erythrocytes are more prone to photooxidant injury with b
ilirubin as the sensitizer, we compared the malonyl dialdehyde (MDA) l
evels and haematocrit values in 11 G6PD-deficient samples with a bilir
ubin: albumin molar ratio of 1:2 (10 mg% bilirubin, 2.5 g% albumin) ph
otoexposed at 6 mu W cm(-2) nm(-2) (420-460 nm), with 11 of control sa
mples. Twelve hours after photoexposure the incremental changes in MDA
levels (OD units) were higher in G6PD-deficient samples [mean (SE) =
0.230 (0.171) vs 0.075 (0.043), p < 0.01]. Antioxidant drugs may have
a protective role while G6PD-deficient neonates undergo phototherapy.