FRONDOSINS, 5 NEW SESQUITERPENE HYDROQUINONE DERIVATIVES WITH NOVEL SKELETONS FROM THE SPONGE DYSIDEA-FRONDOSA - INHIBITORS OF INTERLEUKIN-8 RECEPTORS

Bioassay-guided Fractionation of the EtOAc extract of the sponge Dysid ea frondosa collected in Pohnpei yielded five sesquiterpenes, frondosi ns A-E (1-5). The structures and relative stereochemistry of the frond osins were established by interpretation of spectral data. Frondosins A-E (1-5), which possess novel carbon skeletons, were found to be inhi bitors of interleukin-8 receptors and protein kinase C in the low micr omolar range. (C) 1997 Elsevier Science Ltd.