THROMBOCYTOPENIA IN THE ANTIPHOSPHOLIPID SYNDROME

Objective - To determine the prevalence of thrombocytopenia in a group of patients suffering from the antiphospholipid syndrome (APS) and to investigate whether these patients may have any particular clinical o r serological features. Methods - Retrospective analysis. A group of 1 71 APS patients seen in our department were studied for the presence o f thrombocytopenia. Clinical and serological features of these patient s were analysed by standard methods and each of them was correlated to the presence of thrombocytopenia and compared with those found in the group without thrombocytopenia. Results - Each of the patients studie d had a minimum of three platelet counts during the follow up period. Forty (23.4%) were found to have thrombocytopenia; 13 with persistentl y low and 27 patients with intermittently low platelet counts. There w ere no statistically significant differences in sex, age, disease dura tion or diagnosis when compared with the group of APS patients without thrombocytopenia. Thrombocytopenia was associated with thrombosis in 18, with miscarriages in five, and with both of these features in 13 p atients. It was the only manifestation of the APS in four patients. Al l patients had persistently positive tests for antiphospholipid antibo dies concomitantly with the low platelet counts. No significant associ ation was found between the presence of thrombocytopenia and clinical or serological manifestations in APS patients. Conclusion - This study showed a prevalence of thrombocytopenia of 23.4% in APS. These patien ts did not present any significant clinical or serological features th at distinguish them from those patients without thrombocytopenia.