T. Porkkaheiskanen et al., THE EFFECT OF REM-SLEEP DEPRIVATION ON HISTAMINE CONCENTRATIONS IN DIFFERENT BRAIN-AREAS, Life sciences, 54(22), 1994, pp. 1719-1726
Citations number
29
Categorie Soggetti
Biology,"Medicine, Research & Experimental","Pharmacology & Pharmacy
Rats were deprived of REM sleep (REMS) for 72 h with the platform meth
od and decapitated in the morning immediately after the deprivation or
in the afternoon after having been allowed 5 hours of rebound sleep.
The histamine concentrations of the anterior and posterior hypothalamu
s, the cortex, the hippocampus and the pineal gland were measured, as
well as the tele-methylhistamine concentrations of the anterior and po
sterior hypothalamus. Histamine concentrations were no different after
REMS deprivation compared to large platform or dry cage controls, but
in the anterior hypothalamus histamine levels increased during reboun
d sleep only in the REMS deprived rats. tele-Methylhistamine/histamine
ratios were higher after 72 h of both REMS deprivation and the large
platform treatment compared to dry cage controls, indicating increased
histamine utilization during the platform treatment procedure.