REACTION OF 3',5'-DI-O-ACETYL-2'-DEOXYINOSINE WITH THE CHLORINATING AGENT PPH(3)-CCL4 - SYNTHESIS OF THE 6-CHLORODERIVATIVE AND OF A NEW BASE LINKED DIMER, USEFUL INTERMEDIATE TO N-15-1-LABELED 2'-DEOXYINOSINE

Authors
DENAPOLI L MESSERE A MONTESARCHIO D PICCIALLI G SANTACROCE C VARRA M
Citation
L. Denapoli et al., REACTION OF 3',5'-DI-O-ACETYL-2'-DEOXYINOSINE WITH THE CHLORINATING AGENT PPH(3)-CCL4 - SYNTHESIS OF THE 6-CHLORODERIVATIVE AND OF A NEW BASE LINKED DIMER, USEFUL INTERMEDIATE TO N-15-1-LABELED 2'-DEOXYINOSINE, Journal of the Chemical Society. Perkin transactions. I, (8), 1994, pp. 923-925
Citations number
18
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of the Chemical Society. Perkin transactions. I → ACNP
ISSN journal
0300922X
Issue
8
Year of publication
1994
Pages
923 - 925
Database
ISI
SICI code
0300-922X(1994):8<923:RO3WTC>2.0.ZU;2-K
Abstract
Treatment of 3',5'-di-O-acetyl-2'-deoxyinosine 1 with PPh(3)-CCl4 in t he presence of catalytic 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) affo rded eoxy-3'.5'-di-O-acenyl-beta-D-ribofuranosyl)purine 3. Use of an e xcess of DBU gave the new dimeric bipurine 5 (90%) which proved to be a useful intermediate for obtaining, in one step. [N-15-1]-2'-deoxyino sine.