Citation
M. Ptashne et A. Gann, TRANSCRIPTIONAL ACTIVATION BY RECRUITMENT, Nature, 386(6625), 1997, pp. 569-577
Citations number
101
Categorie Soggetti
Multidisciplinary Sciences
ISSN journal
00280836
Volume
386
Issue
6625
Year of publication
1997
Pages
569 - 577
Database
ISI
SICI code
0028-0836(1997)386:6625<569:TABR>2.0.ZU;2-#
Abstract
The recruitment model for gene activation stipulates that an activator
works by bringing the transcriptional machinery to the DNA. Recent ex
periments in bacteria and yeast indicate that many genes can be activa
ted by this mechanism. These findings have implications for our unders
tanding of the nature of activating regions and their targets, and for
the role of histones in gene regulation.