THERMAL-ANALYSIS OF AMORPHOUS PHASE IN A PHARMACEUTICAL DRUG

Authors
FAGEGALTIER N LAMURE A LACABANNE C CARON A MIFSUD H BAUER M
Citation
N. Fagegaltier et al., THERMAL-ANALYSIS OF AMORPHOUS PHASE IN A PHARMACEUTICAL DRUG, Journal of thermal analysis, 48(3), 1997, pp. 459-464
Citations number
21
Categorie Soggetti
Chemistry Analytical
Journal title
Journal of thermal analysis → ACNP
ISSN journal
03684466
Volume
48
Issue
3
Year of publication
1997
Pages
459 - 464
Database
ISI
SICI code
0368-4466(1997)48:3<459:TOAPIA>2.0.ZU;2-D
Abstract
Thermally Stimulated Current (TSC) spectroscopy and Differential Scann ing Calorimetry (DSC) have been applied to the characterization of the microstructure of a pharmaceutical drug. The dielectric relaxation sp ectrum shows two modes located in the temperature range of the glass t ransition. They have been attributed to the molecular mobility in the ''true amorphous phase'' and in the <<rigid amorphous region>>.