SOLID AND LIQUID-STATE INVESTIGATIONS OF MANDELIC-ACID CYCLODEXTRIN COMPLEXES

In the present study the solid and liquid phase behaviour of mandelic acid cyclodextrin systems were studied. The samples were prepared usin g dry grinding/kneading technique in the absence of any solvent. Therm oanalytical methods (TG, DSC, EGD) were used to characterise the solid compounds. In liquid phase the stoichiometry and the stability consta nts of the complexes formed were determined using UV spectrophotometry . Partial complex formation was found in case of all cyclodextrins use d. The amount of uncomplexed mandelic acid varied between 10-20% of th e total guest content.