RACEMIC COMPOUND FORMATION CONGLOMERATE FORMATION .4. OPTICAL RESOLUTION AND DETERMINATION OF THE MELTING PHASE-DIAGRAMS OF 2',6'-PIPECOLOXYLIDIDE AND 4 1-ALKYL-2',6'-PIPECOLOXYLIDIDES

The phenomena of conglomerate formation-racemic compound formation wer e investigated in a series of five (N-alkyl)-2',6'-pipecoloxylidides. The optically active enantiomers were prepared by optical resolution o f the racemates using 2R,3R-tartaric acid and 0,0'-dibenzoyl-2R,3R-tar taric acid as resolving agent, By DSC measurement of the racemates and the enantiomer the binary phase diagrams were determined. Among the f our racemic molecular compounds the N-methyl derivative is the more st able. By increasing the length of the alkyl chain the stability of the racemic compound decreased, and in case of the longest -butyl- chain conglomerate formation was observed.