ANTIMALARIAL ACTIVITY OF 1,4-EPIDIOXY-BISABOLA-2,12-DIENE DERIVATIVES

Authors
RUCKER G BREITMAIER E MANNS D MAIER W MAREK A HEINZMANN B HEIDEN K SEGGEWIES S
Citation
G. Rucker et al., ANTIMALARIAL ACTIVITY OF 1,4-EPIDIOXY-BISABOLA-2,12-DIENE DERIVATIVES, Archiv der pharmazie, 330(1-2), 1997, pp. 12-16
Citations number
15
Categorie Soggetti
Chemistry,"Pharmacology & Pharmacy
Journal title
Archiv der pharmazie → ACNP
ISSN journal
03656233
Volume
330
Issue
1-2
Year of publication
1997
Pages
12 - 16
Database
ISI
SICI code
0365-6233(1997)330:1-2<12:AAO1D>2.0.ZU;2-K
Abstract
1,4-Epidioxy-bisabola-2,12-diene (3) and aromatic hydroperoxides (4, 5 ) were prepared by photoxidation of gamma-curcumene (1). Reduction and esterification of 6 and 7 afforded compounds 9 to 10. All compounds w ere tested in vitro for antimalarial activity. The activity could not be increased significantly, compared with 3. The most active compounds , 3 and 9, did not show in vivo antimalarial activity in mice.