Prominent soft-tissue uptake of Tc-99m-methylene diphosphonate (MDP) w
ithin the prostate bed was found after cryoablation for prostate carci
noma. CT, MRI and sonographic studies demonstrated liquifactive necros
is of the prostate bed. The probable etiology for Tc-99m-MDP uptake in
this case is necrosis with subsequent neovascular hyperemia and micro
scopic calcium deposits. Three-phase scintigraphy with Tc-99m-MDP appe
ars to be useful for localizing the extent bf soft tissue inflammation
and necrosis.