INFLUENCE OF MODERATE HEMODILUTION WITH FLUOSOL OR NORMAL SALINE ON CARBARYL DISPOSITION IN SPRAGUE-DAWLEY RATS

In rats carbaryl undergoes extensive biotransformation involving both albumin-mediated hydrolysis and cytochrome P-450-mediated metabolism; studies have suggested that approximately one-half of a carbaryl dose is hydrolysed and one-half is metabolized. Fluosol is known to be an i nducer of cytochrome P-450, and Fluosol haemodilution reduces plasma a lbumin concentrations. The disposition of carbaryl was, therefore, det ermined in rats for 72 h after 40 mL kg(-1) haemodilution with Fluosol or normal saline (0.9% NaCl). Volumes of distribution were significan tly reduced after saline haemodilution for 72 h but only at 48 h after Fluosol haemodilution. Fluosol and saline haemodilution had little in fluence on carbaryl total body clearance (CL). These results indicate that both hepatic and non-hepatic clearance pathways were not influenc ed by the haemodiluents or the haemodilution procedure.