BLASTOGENIC RESPONSE TO MITOGENS OF SPLENIC CELLS ISOLATED FROM RATS TREATED WITH AMIODARONE

Authors
PADMAVATHY B SIRAJUDEEN KNS DEVARAJ H DEVARAJ SN
Citation
B. Padmavathy et al., BLASTOGENIC RESPONSE TO MITOGENS OF SPLENIC CELLS ISOLATED FROM RATS TREATED WITH AMIODARONE, Medical science research, 25(3), 1997, pp. 153-154
Citations number
17
Categorie Soggetti
Medicine, Research & Experimental
Journal title
Medical science research → ACNP
ISSN journal
02698951
Volume
25
Issue
3
Year of publication
1997
Pages
153 - 154
Database
ISI
SICI code
0269-8951(1997)25:3<153:BRTMOS>2.0.ZU;2-Z
Abstract
Administration of an antiarrhythmic agent, amiodarone, (175 mg kg(-1) body weight/day) dissolved in water, through gavage for 3 weeks to rat s markedly suppressed the blastogenic response of splenic cells to var ious concentrations of the mitogens phytohaemagglutinin,concanavalin A and lipopolysaccharide, as measured by [H-3]-thymidine incorporation. This indicates the drug's ability to produce immunosuppression of spl enic cells. The drug also caused marked changes in spleen morphology.