SERUM LEVELS OF INTERLEUKINS, GROWTH-FACTORS AND ANGIOGENIN IN PATIENTS WITH ENDOMETRIAL CANCER

The purpose of this work was to study changes in serum levels of inter leukins, growth factors and angiogenin during different stages of endo metrial cancer progression. Serum levels were assayed by enzyme-linked immunosorbant assay in 59 women with stages I-IV of endometrial cance r (study subjects: stage I, n = 20; stage II, n = 8; stage III, It = 5 ; stage IV, n = 6) and compared to the serum levels in 20 women withou t cancer as control subjects. Patients with endometrial cancer had var ied serum levels of interleukins and growth factors. There was a signi ficant increase in serum levels of angiogenin in all stages of tumor p rogression. Levels of interleukin-8 (IL-8), IL-10 and transforming gro wth factor beta (TGF beta) were significantly elevated in patients wit h stages I and II carcinoma. The serum levels of tumor necrosis factor alpha (TNF alpha), granulocyte/macrophage-colony-stimulating factor, basic fibroblast growth factor (BFGF), IL-7 and IL-2 were significantl y elevated in patients with stages II and III carcinoma and the serum level of tumor necrosis factor beta (TNF beta) was slightly elevated i n patients with stage II carcinoma only. The serum levels of IL-1 alph a, IL-1 beta and IL-6 were not elevated in endometrial cancer patients in any of the clinical stages. The results showed that progression of endometrial cancer is associated with increased serum levels of cytok ines, growth factors and angiogenin, which possibly amplify angiogenes is during different clinical stages.