OVULATION BY REPEATED HUMAN CHORIONIC-GONADOTROPIN IN EMPTY FOLLICLE SYNDROME YIELDS A TWIN CLINICAL PREGNANCY

This case illustrates the possibility of obtaining oocytes that fertil ize and cleave normally after the administration of a second ovulatory dose of human chorionic gonadotrophin (HCG) in a case of 'empty folli cle syndrome', The present patient underwent ovarian stimulation with gonadotrophin-releasing hormone analogue (GnRHa)/menotropin for intrac ytoplasmic sperm injection (ICSI), After the failure of the first oocy te retrieval, a second dose of HCG was administered to trigger ovulati on. A total of 13 oocytes was retrieved during the second procedure an d 11 good quality embryos were obtained (fertilization and cleavage ra tes of 92 and 91% respectively), No pregnancy was achieved after the r eplacement of three embryos, In a subsequent cycle stimulated with clo miphene citrate, three Frozen-thawed embryos were replaced and a twin pregnancy was achieved. The patient delivered two healthy babies at te rm.