V. Soderstromanttila et al., LEVONORGESTREL-RELEASING INTRAUTERINE-DEVICE CAN BE USED IN OOCYTE DONORS DURING OVARIAN STIMULATION, Human reproduction, 12(3), 1997, pp. 491-495
Seven oocyte donors with a levonorgestrel-releasing intrauterine devic
e (LNG-IUD) in situ (group A) underwent ovarian stimulation with human
menopausal gonadotrophin (HMG) after goserelin down-regulation, in ei
ght treatment cycles, The donors in a control group (group B, n = 16)
were comparable in age, body mass index and parity characteristics. Th
ere were no statistically significant differences in response to ovari
an hyperstimulation between the two groups, The number of oocytes reco
vered was 12.4 +/- 5.1 (SD) following stimulation with 27.9 +/- 9.3 am
poules of HMG over 11.2 +/- 1,3 days in group A, Following stimulation
with 26.2 +/- 6.3 ampoules of HMG over 11.0 +/- 1.0 days, the number
of oocytes collected was 13.9 +/- 10.4 in group B. The fertilization r
ate (2PN/cell) of cells in group A was 63% (62/99) and in group B, 53%
(117/220, not significant), The cleavage rate of cells in group A (60
%, 59/99) was significantly higher than in group B (47%, 104/220) (P <
0.05), On average, two embryos were transferred per cycle, In group A
, the pregnancy rate per transfer was 40% (4/10) and in group B, 29% (
6/21; not significant), In conclusion, LNG-IUD can be used as a contra
ceptive method during ovarian stimulation of volunteer oocyte donors.