CYCLOPLATINATED COMPLEXES OF THIOSEMICARBAZONES - SYNTHESIS AND CRYSTAL-STRUCTURE OF [PH(2)PC(6)H(4)CHNNC(S)NHCH3PTCL]

The synthesis and characterization of the platinum heterocyclic carbox aldehyde thiosemicarbazone complexes [NC(5)H(4)CRNNC(S)NHR(1)PtCl] (R= H, R'=CH3(1); R=CH3, R'=CH3(2); R=CH3, R=H(3)) and diphenylphosphinoph enyl carboxaldehyde thiosemicarbazone complexes [Ph(2)PC(6)H(4)CHNNC(S )NHRPtCl] (R=CH3(S); R='C3H7 (6); R=Ph(7)) are described. Compounds 1- 3 were prepared by reaction of Pt(SEt(2))(2)Cl-2 with 2-acetylpyridine -4-alkylthiosemicarbazone in the presence of NEt(3). Compounds 5-7 wer e prepared using Pt(SEt(2))(2)Cl-2 in toluene with diphenylphosphinoph enyl carboxaldehyde alkylthiosemicarbazone. The compounds have been ch aracterized by microanalysis, NMR (H-1,C-13, P-31) spectroscopy, and s ingle-crystal X-ray diffraction. X-ray single crystal diffraction anal ysis reveals that compound 5 is a mononuclear platinum compound with P ,N,S-coordination mode.