P. Desgranges et al., AORTIC STENTS COVERING THE RENAL-ARTERIES OSTIA - AN ANIMAL STUDY, Journal of vascular and interventional radiology, 8(1), 1997, pp. 77-82
PURPOSE: To evaluate the consequences of placing an aortic stent over
the renal arteries. MATERIALS AND METHODS: The renal ostia of 11 pigs
were covered by Strecker stents placed in the aorta, At 1 month, the d
egree of renal ostial stenosis was determined by means of angiography
and gross pathologic and histologic examination, Any reduction in area
of the renal ostia was considered significant, Preprocedure and 1-mon
th serum creatinine levels were also examined. RESULTS: One stent migr
ated and was excluded from the study, There was one angiographic failu
re and, among the remaining 18 renal arteries evaluated, one was occlu
ded, six were stenosed, and 11 were patent, Of the 10 samples availabl
e for pathologic examination, one was excluded from study because one
stent was not fully deployed, A neointima was covering the struts cros
sing or encircling the renal arteries ostia with a mean area coverage
of 43% +/- 30% (range, 0-84%), Serum creatinine levels rose from 71.1
mu moI/L +/- 7.1 preoperatively to 94.2 mu mol/L +/- 6.7 postoperative
ly (P < .01). CONCLUSION: An aortic stent placed over the renal arteri
es in pigs may compromise renal perfusion in the long-term because neo
intima tends to fill the spaces between the struts.