SEARCH FOR NEW ANTICONVULSANT COMPOUNDS .1. SYNTHESIS, PHYSICOCHEMICAL AND ANTICONVULSANT PROPERTIES OF NEW DERIVATIVES OF ALPHA-AMINO-GAMMA-PHTHALIMIDOBUTYRIC ACID

Synthesis and physicochemical properties of new derivatives of alpha-s ubstituted gamma-phthalimidobutyric acid are described. N-substituted amides of lpha-(4-phenylpiperazine)-gamma-phthalimidobutyric acid were prepared by condensation of the acid with the corresponding derivativ es of benzylamine in the presence of BOP reagent. 2-(4-Phenylpiperazin e)- or 2- (4-benzylpiperidine)-4-phthalimidobutyric acid were esterifi ed with alkyl bromide in the presence of DBU or tetrabutylammonium bro mide as catalyst. The obtained compounds were evaluated for anticonvul sant activity. 2-(4-Phenylpiperazine)4-phthalimidobutyric acid and thr ee N-substituted amides of this acid displaced protection against MES and scMet-induced seizures.