SYNTHESIS AND BIOLOGICAL-ACTIVITY OF 1,2,4-TRIARINOTRIAZINONE DERIVATIVES

Authors
ABDELHALIM AM ELGENDY Z ABDELRAHMAN RM
Citation
Am. Abdelhalim et al., SYNTHESIS AND BIOLOGICAL-ACTIVITY OF 1,2,4-TRIARINOTRIAZINONE DERIVATIVES, Die Pharmazie, 50(11), 1995, pp. 726-729
Citations number
14
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Die Pharmazie → ACNP
ISSN journal
00317144
Volume
50
Issue
11
Year of publication
1995
Pages
726 - 729
Database
ISI
SICI code
0031-7144(1995)50:11<726:SABO1D>2.0.ZU;2-Z
Abstract
The synthesis of 1,2,4-triazines bearing a 1,2,4-triazinone moiety and of 1,2,4-triazolo[4,3-b]-1,2,4-triazonones have been achieved by reac tion of -hydrazino-6-spiro-(9-fluorenyl)-1,2,4-triazin-5(4 H)one with various oxo- and halo-compounds. Structures of the products have been deduced by elemental analysis and spectral data. Significant anti-HIV and anticancer activities were observed in vitro for some members of t he series.