OUTCOME OF AMNIOTIC-FLUID ANALYSIS AND NEONATAL RESPIRATORY STATUS INDIABETIC AND NONDIABETIC PREGNANCIES

OBJECTIVE: To evaluate the likelihood of mature or immature amniotic f luid analysis and subsequent presence or absence of neonatal pulmonary disease in a large population of diabetic and nondiabetic pregnancies . STUDY DESIGN: Six hundred sixty-eight pregnancies that delivered wit hin seven days of phosphatidylglycerol (PG) and lecithin/sphingomyelin ration (L/S) testing were analyzed. (PG testing was by Amniostat-FLM and L/S testing by a modified Gluck technique.) Neonatal respiratory o utcome and amniocentesis results were stratified by maternal diabetes status and gestational age for comparison. We determined the likelihoo d of finding correctly mature and correctly immature amniotic fluid an alysis for each gestational age category. RESULTS: We found high rates of incorrectly immature results for PG (53%) and L/S (21%) preterm an d for PG at term (20%). Diabetic and nondiabetic pregnancies did not d iffer. CONCLUSION: Population-based information on the a priori chance s of amniotic fluid and neonatal pulmonary outcome in diabetic and non diabetic pregnancies is given for use in determining the utility of am niotic fluid analysis in individual clinical settings.