PREGNANCY AND DELIVERY IN CASE OF IDIOPAT HIC THROMBOCYTOPENIC PURPURA

Clinical data from eight pregnant women with idiopathic thrombocytopen ic purpura (ITP) were retrospectively analysed. The mean age of the wo men was 28.2 years. Five women underwent splenectomy during childhood. The lowest maternal platelet count observed ranged from 8000 to 88000 /mm(3) Genital bleeding occurred in only one case. Treatment was based on administration of corticosteroids with or without human-pooled imm unglobulins. Caesarian section was performed in all cases. Six newborn s were healthy and had a successful subsequent course. Two infants die d, one in utero because of abruptio placentae and the other one 1 mont h post partum because of a cerebral haematoma. After a mean follow-up of eighteen months, thrombocytopenia is still present in two women, de spite the continuous treatment. In conclusion, ITP rather rarely coinc ides with pregnancy. Treatment is usually successful for the mother bu t the risk for the fetus remains considerably high.