When John Snow undertook the studies of the cholera epidemic of 1854 i
n London, he was testing his theory of communicable disease, which had
been enunciated in an oration delivered at the 80th anniversary of th
e Medical Society of London. Snow had been elected orator of the year
for 1853 and, according to his biographer, had spent the better part o
f a year in preparation. The oration was titled, ''On Continuous Molec
ular Changes, More Particularly in Their Relation to Epidemic Diseases
.'' Although the text of this oration is readily available in the 1936
Commonwealth Fund facsimile reprint of Snow's more famous cholera stu
dies, few modern epidemiologists are familiar with the work. In it, Sn
ow lays out a theory which includes recognition that for each communic
able disease there is a distinct and specific cause, that the causal a
gent is a living organism which is stable over many generations of pro
pagation, that infection is necessary for communication to occur, and
that the quantity of infectious material transmitted is increased by m
ultiplication after infection to produce disease manifestations. Altho
ugh Snow's theory is similar to Jacob Henle's formulations of a decade
earlier, it is more precise, more comprehensive, and more explicit. O
n the basis of this work alone, Snow deserves broader recognition than
he has received.