Ev. Hersh et al., ASSESSING THE DURATION OF MANDIBULAR SOFT-TISSUE ANESTHESIA, The Journal of the American Dental Association, 126(11), 1995, pp. 1531-1536
Dentists often employ solutions of 3 percent mepivacaine or 4 percent
prilocaine without a vasoconstrictor in pediatric patients in an attem
pt to reduce the duration of mandibular soft tissue anesthesia. The au
thors compared the time course of soft tissue anesthesia produced by t
hese solutions with that of 2 percent lidocaine plus 1:100,000 epineph
rine in 60 adults. They found no reduction in the duration of soft tis
sue anesthesia when employing 3 percent mepivacaine or 4 percent prilo
caine instead of 2 percent lido-epi. Combining these observations with
local anesthetic dosage considerations, the authors recommend that 2
percent lido-epi be used when performing mandibular block injections i
n young children.