C. Merola et al., AN AUDIT OF ADVERSE EVENTS IN CHILDREN SEDATED WITH CHLORAL HYDRATE OR PROPOFOL DURING IMAGING STUDIES, Paediatric anaesthesia, 5(6), 1995, pp. 375-378
We examined records of sedations provided by the paediatric anaesthesi
ology staff for 455 children (ages 1 mo-17 yr) undergoing MRI or CT sc
ans at our institution over a twelve-month period with regard to the m
onitoring of adverse events: excessive sedation, agitation, vomiting,
hypoxaemia, and major airway compromise. One hundred-and-thirty-one pa
tients (29%) received chloral hydrate; 324 patients (71%) received pro
pofol. All patients were monitored with continuous noninvasive pulse o
ximetry and received supplemental oxygen via nasal cannulae. Of the pa
tients who received chloral hydrate, 64 (49%) were over one year of ag
e; of the patients who received propofol, 318 (98%) were one year of a
ge or older. In the chloral hydrate group, 23 patients (19%) were deem
ed excessively sedated and four patients (3%) were agitated; no patien
ts in the propofol group experienced any of the adverse outcomes revie
wed. Furthermore, no patients in either group had significant airway c
ompromise and none was admitted to the hospital as a result of the sed
ation.