HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC METHOD FOR THE ENANTIOSELECTIVE ANALYSIS OF MEFLOQUINE IN PLASMA AND URINE

Authors
WALLEN L ERICSSON O WIKSTROM I HELLGREN U
Citation
L. Wallen et al., HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC METHOD FOR THE ENANTIOSELECTIVE ANALYSIS OF MEFLOQUINE IN PLASMA AND URINE, Journal of chromatography B. Biomedical applications, 655(1), 1994, pp. 153-157
Citations number
9
Categorie Soggetti
Chemistry Analytical
Journal title
Journal of chromatography B. Biomedical applications
ISSN journal
15726495 → ACNP
Volume
655
Issue
1
Year of publication
1994
Pages
153 - 157
Database
ISI
SICI code
Abstract
An HPLC method for analysis of the enantiomers of the antimalarial dru g mefloquine is presented. A complete resolution of(-)-(11S,2'R) and ( +)-(11R,2'S) erythro-mefloquine from plasma and urine was obtained on a commercial AGP column. Mefloquine enantiomers were detected by UV at 222 nm. The separation factor (alpha) at + 20 degrees C was 1.50. The limit of determination (coefficient of variation 4.0%) for the enanti omeric ratio (11S,2'R)l (11R,2'S) is 15:1 at a total mefloquine concen tration of 1.6 mM.