FUNGAL METABOLITES .14. NOVEL POTENT IMMUNOSUPPRESSANTS, MYCESTERICINS, PRODUCED BY MYCELIA-STERILIA

Authors
SASAKI S HASHIMOTO R KIUCHI M INOUE K IKUMOTO T HIROSE R CHIBA K HOSHINO Y OKUMOTO T FUJITA T
Citation
S. Sasaki et al., FUNGAL METABOLITES .14. NOVEL POTENT IMMUNOSUPPRESSANTS, MYCESTERICINS, PRODUCED BY MYCELIA-STERILIA, Journal of antibiotics, 47(4), 1994, pp. 420-433
Citations number
9
Categorie Soggetti
Pharmacology & Pharmacy",Immunology
Journal title
Journal of antibiotics → ACNP
ISSN journal
00218820
Volume
47
Issue
4
Year of publication
1994
Pages
420 - 433
Database
ISI
SICI code
0021-8820(1994)47:4<420:FM.NPI>2.0.ZU;2-8
Abstract
Mycestericins A, B, C, D and E were isolated from the culture broth of Mycelia sterilia ATCC 20349 along with thermozymocidin (=myriocin). T heir structures were elucidated on the basis of spectroscopic studies and chemical evidence. Tile acetate of mycestericin C was identical wi th the acetate of 6,7-dihydromyriocin. Mycestericins suppressed the pr oliferation of lymphocytes in the mouse allogeneic mixed lymphocyte re action, with a potency similar to that of myriocin.