Immunization of infants and children is the most effective strategy fo
r decreasing the incidence of some infectious diseases. Most invasive
disease due to Haemophilus influenzae type b occurs before age 5 years
, and routine vaccination of infants for hepatitis B is currently reco
mmended because selective immunization of high-risk persons has not be
en feasible, Decades of use of poliovirus vaccine has effectively elim
inated cases of wild-virus infection, although some vaccine-related ca
ses still occur. The newly approved varicella vaccine appears to be a
cost-effective way to decrease infection rates in children. Improved i
mmunization rates for influenza and pneumococcal and meningococcal dis
eases could help decrease excess mortality in elderly persons and thos
e with chronic illness.