Ck. Grisolia et Cs. Takahashi, ASSESSMENT OF INTERACTIONS OF THE ANTIMALARIAL-DRUGS CHLOROQUINE AND MEFLOQUINE WITH NANO2 AND HGCL2 IN RODENTS, MUTATION RESEARCH, 305(2), 1994, pp. 151-156
Chloroquine and mefloquine are antimalarial drugs widely used in Brazi
l, especially in prospecting areas in the Amazonian region, where they
may be associated with other compounds suspected to be genotoxic. Mef
loquine was tested at doses of 150, 300, 600, and 1200 mg/kg body weig
ht on Wistar rats and the animals were killed 6, 12 and 24 h later. No
significant increase in chromatid gaps or breaks was induced by any o
f the treatments. The drugs were associated with NaNO2 and HgCl2, and
a slight induction of chromatid aberration frequencies occurred with N
aNO2, particularly when associated with chloroquine. The HgCl2 did not
show clastogenic activity in bone marrow cells of Wistar rats or indu
ce micronuclei in BALB/c mice. The association of chloroquine and mefl
oquine did not induce any clastogenic effect.