PERIPHERAL-T-CELL LYMPHOMA WITH HEMOPHAGOCYTIC HISTIOCYTOSIS LOCALIZED TO THE BONE-MARROW ASSOCIATED WITH INAPPROPRIATE SECRETION OF ANTIDIURETIC-HORMONE

A patient with high fever, loss of weight and profound pancytopenia is reported. Peripheral T-cell lymphoma with hemophagocytosis was diagno sed. Bone marrow was the only localisation of the lymphoma. At present ation there were (i) a coagulopathy consistent with hemophagocytic his tiocytosis (ii) the features of the syndrome of inappropriate antidiur etic hormone secretion (SIADH). These different abnormalities disappea red after chemotherapy and reappeared during each of the 2 periods of disease progression. The patient died 6 months after diagnosis without ever achieving complete remission. As far as we are aware this is the first case report of T-cell lymphoma with hemophagocytic syndrome loc alised to the bone marrow and associated with SIADH.