Jm. Gries et al., CIMETIDINE DOES NOT ALTER SPARFLOXACIN PHARMACOKINETICS, International journal of clinical pharmacology and therapeutics, 33(11), 1995, pp. 585-587
The interaction between cimetidine and sparfloxacin was studied in 10
healthy volunteers who received a single oral dose of 400 mg sparfloxa
cin on the third day of an 8 day cimetidine (400 mg t.i.d.) or placebo
randomly assigned treatment. No statistically significant differences
were observed in the pharmacokinetic parameters (C-max - AUC - T-1/2
- urinary excretion and metabolic ratio) of sparfloxacin following the
2 treatment. Cimetidine does not affect absorption, metabolism or uri
nary excretion of sparfloxacin; consequently, patients exposed to this
drug combination are not at risk.