TREATMENT OF INVASIVE PULMONARY ASPERGILLOSIS IN SEVERELY NEUTROPENICCHILDREN WITH MALIGNANT DISORDERS USING LIPOSOMAL AMPHOTERICIN-B (AMBISOME), GRANULOCYTE-COLONY-STIMULATING FACTOR, AND SURGERY - REPORT OF5 CASES

Five children with malignancies developed invasive pulmonary aspergill osis during chemotherapy-induced neutropenia. All patients were treate d with liposomal amphotericin B and human recombinant granulocyte colo ny-stimulating factor. Two patients did not recover from bone marrow a plasia and died from organ-infiltrating fungal invasion. Two patients who recovered from bone marrow aplasia survived after surgery of the p ulmonary lesions. The fifth patient had a complete resolution of invas ive pulmonary aspergillosis after neutrophil recovery without surgical intervention. We conclude that not only the antifungal treatment but also the recovery of granulocytes are important in localizing invasive forms of Aspergillus infections in patients with profound immunosuppr ession.