Four patients have presented secondarily to this unit in recent years
with rhabdomyolysis following prolonged compartment syndromes conseque
nt upon drug overdoses or severe injury. Multiple complications arose
due to the severe nature of the compartment syndrome itself and also i
ts late and sometimes incomplete initial treatment. In two, cases out
of four a secondary amputation was required. Our experience with these
cases demonstrates the importance of repeat examination under anaesth
etic of the affected limbs following fasciotomy, even if apparently he
althy granulation tissue is forming, and the value of persistent oedem
a and elevated creatine phosphokinase levels as markers of continued p
athology. Observation of these factors may enable amputations and prol
onged nerve palsies to be avoided in future patients.