THE GENEXPRESS INDEX - A RESOURCE FOR GENE DISCOVERY AND THE GENIC MAP OF THE HUMAN GENOME

Detailed analysis of a set of 18,698 sequences derived from both ends of 10,979 human skeletal muscle and brain cDNA clones defined 6676 fun ctional families, characterized by their sequence signatures over 5750 distinct human gene transcripts. About half of these genes have been assigned to specific chromosomes utilizing 2733 eSTS markers, the poly merase chain reaction, and DNA from human-rodent somatic cell hybrids. Sequence and clone clustering and a functional classification togethe r with comprehensive data base searches and annotations made it possib le to develop extensive sequence and map cross-indexes, define electro nic expression profiles, identify a new set of overlapping genes, and provide numerous new candidate genes for human pathologies.