A HIGH-RESOLUTION GENETIC-MAP OF MOUSE CHROMOSOME-15 ENCOMPASSING THEDOMINANT MEGACOLON (DOM) LOCUS

Authors
PULITI A PREHU MO SIMONCHAZOTTES D FERKDADJI L PEUCHMAUR M GOOSSENS M GUENET JL
Citation
A. Puliti et al., A HIGH-RESOLUTION GENETIC-MAP OF MOUSE CHROMOSOME-15 ENCOMPASSING THEDOMINANT MEGACOLON (DOM) LOCUS, Mammalian genome, 6(11), 1995, pp. 763-768
Citations number
24
Categorie Soggetti
Biology,"Genetics & Heredity","Biothechnology & Applied Migrobiology
Journal title
Mammalian genome → ACNP
ISSN journal
09388990
Volume
6
Issue
11
Year of publication
1995
Pages
763 - 768
Database
ISI
SICI code
0938-8990(1995)6:11<763:AHGOMC>2.0.ZU;2-A
Abstract
Dominant megacolon (Dom) is one of four mutations in the mouse that ca n produce a phenotype similar to Hirschsprung disease in human. The Do m gene product is not known, and no candidate region has been defined for a possible human homolog. In this publication we report mapping th e Dom locus with high definition, using several intra- and interspecif ic crosses and a set of 16 Chr 15-specific microsatellites flanking th is locus.