CUTANEOUS ACANTHAMOEBA INFECTION IN THE ACQUIRED-IMMUNODEFICIENCY-SYNDROME - RESPONSE TO MULTIDRUG THERAPY

Acanthamoeba, a free-living ameba of soil and water, produces the rare infections of granulomatous amebic encephalitis and amebic keratitis, We report a 38-year-old white man with the acquired immuno-deficiency syndrome (AIDS) who experienced Acanthamoeba infection that presented as multiple skin nodules without associated encephalitis, Histologic examination revealed necrotizing granulomatous inflammation with numer ous amebic organisms that were cultured and identified as Acanthamoeba group 2, probably Acanthamoeba castellani by monoclonal antibodies. R esults of in vitro susceptibility testing demonstrated resistance to a ll six tested drugs. A partial clinical response, however, was obtaine d with multidrug therapy.