PRODRUGS OF ANTHRACYCLINE ANTIBIOTICS SUITED FOR TUMOR-SPECIFIC ACTIVATION

Authors
AZOULAY M FLORENT JC MONNERET C GESSON JP JACQUESY JC TILLEQUIN F KOCH M BOSSLET K CZECH J HOFFMAN D
Citation
M. Azoulay et al., PRODRUGS OF ANTHRACYCLINE ANTIBIOTICS SUITED FOR TUMOR-SPECIFIC ACTIVATION, Anti-cancer drug design, 10(6), 1995, pp. 441-450
Citations number
18
Categorie Soggetti
Pharmacology & Pharmacy",Oncology,Biology
Journal title
Anti-cancer drug design → ACNP
ISSN journal
02669536
Volume
10
Issue
6
Year of publication
1995
Pages
441 - 450
Database
ISI
SICI code
0266-9536(1995)10:6<441:POAASF>2.0.ZU;2-X
Abstract
The two novel prodrugs 4 and 11 have been prepared from tetra-O-acetyl -D-galactopyranose and doxorubicin in three and six steps, respectivel y. Their low cytotoxicity, high stability in plasma and, in the case o f 11, efficient hydrolysis in the presence of alpha-galactosidase, ful fill preliminary conditions for their use in combination with monoclon al antibody-enzyme conjugates.