UNRELATED PATIENTS WITH DISCOID LUPUS-ERYTHEMATOSUS (DLE) AND SYSTEMIC LUPUS-ERYTHEMATOSUS (SLE) SHARE THE MAJOR HISTOCOMPATIBILITY COMPLEX(MHC) MARKERS - REPORT OF 2 MEXICAN FAMILIES

Authors
GARCIAGONZALEZ E MELINALDANA H VARGASALARCON G VEGAMEMIJE E ALCOCERVARELA J ALARCONSEGOVIA D GRANADOS J
Citation
E. Garciagonzalez et al., UNRELATED PATIENTS WITH DISCOID LUPUS-ERYTHEMATOSUS (DLE) AND SYSTEMIC LUPUS-ERYTHEMATOSUS (SLE) SHARE THE MAJOR HISTOCOMPATIBILITY COMPLEX(MHC) MARKERS - REPORT OF 2 MEXICAN FAMILIES, EJD. European journal of dermatology, 5(7), 1995, pp. 572-574
Citations number
15
Categorie Soggetti
Dermatology & Venereal Diseases
Journal title
EJD. European journal of dermatology → ACNP
ISSN journal
11671122
Volume
5
Issue
7
Year of publication
1995
Pages
572 - 574
Database
ISI
SICI code
1167-1122(1995)5:7<572:UPWDL(>2.0.ZU;2-7
Abstract
Lupus erythematosus is a polymorphic disease that has been known since the last century. Several cases of systemic lupus erythematosus (SLE) can occur in a family, but the association of SLE and discoid lupus e rythematosus (DIE) in family members is Infrequent. Here, we report on two, unrelated Mexican families each one with some members having SLE and several others with DLE. All Five patients shared the MHC haploty pe: (HL4-A1, B8, Cw7, DR3, DQ2, DRw52, SC01, BFS, C2*C, C4A*0, C4B*1) suggesting that common genetic mechanisms are responsible of these fi ndings.