We report a case of mixed intranasal infection caused by Fusarium sola
ni and a zygomycete, with probable sinus and brain involvement. The pa
tient had chronic myelogenous leukaemia and was treated with chemother
apy. Diagnosis of the infection was established by direct examination
of the intranasal eschar and histopathological study of an excisional
biopsy. Only F. solani was isolated from both specimens. Difficulties
in diagnosis and treatment of these infections are discussed.