SYNTHESIS OF A FOSTEDIL ANALOG - DIETHYL 4-(1,2,3-DIDAZAPHOSPHOL-5-YL) BENZYLPHOSPHONATE - ANALYSIS OF ITS CALCIUM-TRANSPORT INHIBITING ACTIVITY THROUGH BIOLOGICAL-MEMBRANES

Authors
RODI YK LOPEZ L BELLAN J BARRANS J ESSASSI E
Citation
Yk. Rodi et al., SYNTHESIS OF A FOSTEDIL ANALOG - DIETHYL 4-(1,2,3-DIDAZAPHOSPHOL-5-YL) BENZYLPHOSPHONATE - ANALYSIS OF ITS CALCIUM-TRANSPORT INHIBITING ACTIVITY THROUGH BIOLOGICAL-MEMBRANES, Phosphorus, sulfur and silicon and the related elements, 85(1-4), 1993, pp. 225-231
Citations number
18
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Phosphorus, sulfur and silicon and the related elements → ACNP
ISSN journal
10426507
Volume
85
Issue
1-4
Year of publication
1993
Pages
225 - 231
Database
ISI
SICI code
1042-6507(1993)85:1-4<225:SOAFA->2.0.ZU;2-7
Abstract
We describe a four step synthesis of dicoordinated phosphorus Fostedil analogues: the diethyl-4 (1,2,3-diazaphosphol-5-yl)benzylphosphonates 6, in which the benzothiazole Fostedil group is replaced by a 1,2,3 d iazaphosphole ring. Inhibitive activity of calcium transfert, through biological membranes, of compounds 6 is weak.