Over the past 25 years, astronomers have discovered a large number of
gas-phase molecules in space, ranging in size up to more than 10 atoms
. The molecules, which are mainly organic in nature and comprise both
normal and abnormal species, are located between stars, in regions kno
wn as interstellar clouds, which contain both gaseous material and mat
erial in the form of dust particles. The gas is well characterized by
high-resolution spetroscopy, whereas the dust is less well characteriz
ed by low-resolution infrared spectroscopy and the scattering of visib
le radiation. The gaseous molecules are synthesized in situ from precu
rsor atomic material, which derives from the mass loss of previous gen
erations of stars. The chemical reactions involved in this synthesis a
re discussed in some detail as are the models that seek to reproduce t
he observed abundances of molecules.