A. Shitangkoon et G. Vigh, ENANTIOMER SEPARATIONS USING CHLOROACYL PENTYL CYCLODEXTRINS AS CHIRAL GC STATIONARY PHASES, The Journal of microcolumn separations, 7(5), 1995, pp. 493-496
Chloroacyl pentyl beta-cyclodextrin derivatives were synthesized for u
se as gas chromatographic stationary phases. Capillary columns of iden
tical phase ratios were prepared with the liquid undiluted monochloro-
, dichloro-, and trichloroactyl phases and the respective column effic
iency, capacity factor, and separation selectivity values were determi
ned. For most of the enantiomeric pairs studied, monochloroacetyl pent
yl beta-cyclodextrin (M) offers the highest selectivity values, though
at the expense of large capacity factors (long analysis times) and lo
w column efficiencies. Dichloroacetyl pentyl beta-cyclodextrin (D) pro
vides a good compromise between sufficiently high chiral selectivities
and acceptable column efficiencies. Trichloroacetyl pentyl beta-cyclo
dextrin (T) permits the preparation of very efficient columns, but off
ers lower chiral selectivities than the other two chloroacyl derivativ
es. (C) 1995 John Wiley & Sons, Inc.