ENANTIOMER SEPARATIONS USING CHLOROACYL PENTYL CYCLODEXTRINS AS CHIRAL GC STATIONARY PHASES

Chloroacyl pentyl beta-cyclodextrin derivatives were synthesized for u se as gas chromatographic stationary phases. Capillary columns of iden tical phase ratios were prepared with the liquid undiluted monochloro- , dichloro-, and trichloroactyl phases and the respective column effic iency, capacity factor, and separation selectivity values were determi ned. For most of the enantiomeric pairs studied, monochloroacetyl pent yl beta-cyclodextrin (M) offers the highest selectivity values, though at the expense of large capacity factors (long analysis times) and lo w column efficiencies. Dichloroacetyl pentyl beta-cyclodextrin (D) pro vides a good compromise between sufficiently high chiral selectivities and acceptable column efficiencies. Trichloroacetyl pentyl beta-cyclo dextrin (T) permits the preparation of very efficient columns, but off ers lower chiral selectivities than the other two chloroacyl derivativ es. (C) 1995 John Wiley & Sons, Inc.