LINKAGE MAPPING OF THE ANGIOTENSIN AT(2) RECEPTOR GENE (AGTR2) TO THEMOUSE X-CHROMOSOME

Angiotensin II is a potent regulator of cardiovascular homeostasis and binds to two different G-protein-coupled receptors. While the type 1 receptor (AT(1)) mediates the cardiovascular actions of ansotensin II, the function of the recently cloned type 2 receptor (AT(2)) remains u nknown. We have cloned the mouse AT(2) receptor gene (Agtr2) and deter mined its map position by linkage analysis using an interspecific back cross (C57BL/6J x Mus spretus). Agtr2 is located on the proximal mouse X chromosome between DXMit85 and DXMit49, in a region of conserved sy nteny with a part of the human X chromosome implicated in inherited fo rms of premature ovarian failure. The mapping of Agtr2 may expand a re gion of conserved synteny with human Xq26 that includes Hprt. (C) 1995 Academic Press, Inc.