THE INTERFERON-INDUCIBLE, DOUBLE-STRANDED RNA-SPECIFIC ADENOSINE-DEAMINASE GENE (DSRAD) MAPS TO HUMAN-CHROMOSOME LQ21.1-21.2

The interferon-inducible double-stranded RNA-specific adenosine deamin ase is an RNA-modifying enzyme implicated in the generation of biased hypermutations of viral RNAs and the site-selective editing of mammali an mRNAs of neural origin. The gene for the dsRNA-specific adenosine d eaminase has been mapped by fluorescence in situ hybridization (FISH) of genomic clones to a single locus on human chromosome 1 bands q21.1- 21.2. Simultaneous multicolor FISH including lambda clones and yeast a rtificial chromosomes showed a localization of the gene in band 1q21 c entromeric of D1S1705. (C) 1995 Academic Press, Inc.