FAST AXONAL-TRANSPORT RATES ARE UNCHANGED IN 6-MONTH AND 24-MONTH F344 RATS

Authors
JACOB JM
Citation
Jm. Jacob, FAST AXONAL-TRANSPORT RATES ARE UNCHANGED IN 6-MONTH AND 24-MONTH F344 RATS, Brain research, 699(1), 1995, pp. 154-156
Citations number
20
Categorie Soggetti
Neurosciences
Journal title
Brain research → ACNP
ISSN journal
00068993
Volume
699
Issue
1
Year of publication
1995
Pages
154 - 156
Database
ISI
SICI code
0006-8993(1995)699:1<154:FARAUI>2.0.ZU;2-B
Abstract
The maximum rate of fast axonal transport in motor axons at 6 and 24 m onths was measured in F344 rats. Tritiated proline was injected near s ciatic motoneurons and rats were killed after 2-5 h. Nerves were proce ssed for liquid scintillation spectroscopy and fast transport rates ca lculated. The rates, in 6- and 24-month rats, were 373 +/- 12 mm/day a nd 368 +/- 10 mm/day, respectively. Thus, the maximum fast transport r ate is unchanged with age in F344 rats.